Summary of project PR001175
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001175. The data can be accessed directly via it's Project DOI: 10.21228/M8TM5F This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001175 |
| Project DOI: | doi: 10.21228/M8TM5F |
| Project Title: | Cross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition |
| Project Summary: | Child undernutrition is a global health issue associated with a high burden of infectious disease. Undernourished children display an overabundance of intestinal pathogens and pathobionts, and these bacteria induce enteric dysfunction in undernourished mice; however, the cause of their overgrowth remains poorly defined. Here, we show that disease-inducing human isolates of Enterobacteriaceae and Bacteroidales spp. are capable of multi-species symbiotic cross-feeding, resulting in synergistic growth of a mixed community in vitro. Growth synergy occurs uniquely under malnourished conditions limited in protein and iron: in this context, Bacteroidales spp. liberate diet- and mucin-derived sugars and Enterobacteriaceae spp. enhance the bioavailability of iron. Analysis of human microbiota datasets reveals that Bacteroidaceae and Enterobacteriaceae are strongly correlated in undernourished children, but not in adequately nourished children, consistent with a diet-dependent growth synergy in the human gut. Together these data suggest that dietary cross-feeding fuels the overgrowth of pathobionts in undernutrition. |
| Institute: | University of British Columbia |
| Department: | Michael Smith Laboratories |
| Last Name: | Huus |
| First Name: | Kelsey |
| Address: | 3125 East Mall, Vancouver, British Columbia, V6T 1Z4, Canada |
| Email: | khuus@msl.ubc.ca |
| Phone: | +1-604-822-2210 |
Summary of all studies in project PR001175
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001862 | Cross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition | Bacteroides spp. and Escherichia spp. (mixed communities) | University of British Columbia | MS | 2021-11-06 | 1 | 55 | Uploaded data (34.4M)* |
