Summary of project PR001196

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001196. The data can be accessed directly via it's Project DOI: 10.21228/M83X4N This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001196
Project DOI:doi: 10.21228/M83X4N
Project Title:Mitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid Stress
Project Summary:Amino acids are essential building blocks of life. However, increasing evidence suggests that elevated amino acids cause cellular toxicity associated with numerous metabolic disorders. How cells cope with elevated amino acids remains poorly understood. Here, we show that a previously identified cellular structure, the mitochondrial-derived compartment (MDC), functions to protect cells from amino acid stress. In response to amino acid elevation, MDCs are generated from mitochondria, where they selectively sequester and deplete SLC25A nutrient carriers and their associated import receptor Tom70 from the organelle. Generation of MDCs promotes amino acid catabolism, and their formation occurs simultaneously with transporter removal at the plasma membrane via the multi-vesicular body (MVB) pathway. Combined loss of vacuolar amino acid storage, MVBs and MDCs renders cells sensitive to high amino acid stress. Thus, we propose that MDCs operate as part of a coordinated cell network that facilitates amino acid homoeostasis through post-translational nutrient transporter remodeling.
Institute:University of Utah School of Medicine
Laboratory:Hughes Lab
Last Name:Hughes
First Name:Adam
Address:15 N Medical Drive East, RM 4100, Salt Lake City, UT, 84112, USA

Summary of all studies in project PR001196

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001901 Mitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid Stress Saccharomyces cerevisiae University of Utah School of Medicine MS 2021-08-25 1 120 Uploaded data (34.7G)*