Summary of project PR001197

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001197. The data can be accessed directly via it's Project DOI: 10.21228/M8041N This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001197
Project DOI:doi: 10.21228/M8041N
Project Title:Metabolomics analysis of AsPC-1 PDAC cells treated with Porcupine inhibitor (LGK974)
Project Summary:WNT signaling promotes pancreatic ductal adenocarcinoma (PDAC) through diverse effects on proliferation, differentiation, survival, and stemness. A subset of PDAC with inactivating mutations in ring finger protein 43 (RNF43) have growth dependency on autocrine WNT ligand signaling, which renders them susceptible to porcupine inhibitors (PORCNi) that block WNT ligand acylation and secretion. For this study, non-targeted metabolomic analyses were performed to explore the therapeutic response of RNF43-mutant PDAC to the PORCNi LGK974. AsPC-1 (RNF43-mutant) PDAC cells were treated with 25 nM LGK974 to explore stable isotope-resolved metabolomics with uniform 1, D-glucose [U13-C6] labeling.
Institute:University of California, Los Angeles
Department:Pathology & Laboratory Medicine
Laboratory:Dawson Lab
Last Name:David
First Name:Dawson
Address:10833 Le Conte Avenue, Los Angeles, CA, 90095, USA
Email:ddawson@mednet.ucla.edu
Phone:(310) 267-2799

Summary of all studies in project PR001197

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST001902 Metabolomics analysis of AsPC-1 PDAC cells treated with Porcupine inhibitor (LGK974) Homo sapiens University of California, Los Angeles MS 2022-04-19 1 6 Uploaded data (1.8G)*
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