Summary of project PR001208
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001208. The data can be accessed directly via it's Project DOI: 10.21228/M8JX2X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001208 |
| Project DOI: | doi: 10.21228/M8JX2X |
| Project Title: | Myocardial Rev-erb-mediated diurnal metabolic rhythm |
| Project Summary: | Agonists and antagonists of nuclear receptor Rev-erbα/β, key components of the circadian clock, can benefit the heart. Here, we show that mice with cardiomyocyte-specific knockout (KO) of Rev-erbα/β display progressive cardiac dilation and lethal heart failure. Inducible ablation of Rev-erbα/β in adult hearts causes similar phenotypes. Impaired fatty acid oxidation in the KO myocardium, particularly in the light cycle, precedes contractile dysfunctions with a reciprocal overreliance on carbohydrate utilization, particularly in the dark cycle. These findings delineate temporal coordination between clock-mediated anticipation and nutrient-induced response in myocardial metabolism. |
| Institute: | Baylor College of Medicine |
| Last Name: | Song |
| First Name: | Shiyang |
| Address: | One Baylor Plaza, Houston, Texas, 77030, USA |
| Email: | shiyangs@bcm.edu |
| Phone: | 7137983159 |
Summary of all studies in project PR001208
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001915 | Myocardial Rev-erb-mediated diurnal metabolic rhythm( Part1/3) | Mus musculus | Baylor College of Medicine | MS | 2022-12-24 | 1 | 12 | Uploaded data (366K)* |
| ST001916 | Myocardial Rev-erb-mediated diurnal metabolic rhythm (Part 2/3) | Mus musculus | Baylor College of Medicine | MS | 2022-12-24 | 1 | 12 | Uploaded data (17.6K)* |
| ST001917 | Myocardial Rev-erb-mediated diurnal metabolic rhythm (Part 3/3) | Mus musculus | Baylor College of Medicine | MS | 2022-12-24 | 1 | 12 | Uploaded data (403K)* |
