Summary of project PR001218

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001218. The data can be accessed directly via it's Project DOI: 10.21228/M88H76 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001218
Project DOI:doi: 10.21228/M88H76
Project Title:Metabolomics profiles of premenopausal women are different based on O-desmethylangolensin metabotype
Project Summary:Urinary O-desmethylangolensin (ODMA) concentrations provide a functional gut microbiome marker of dietary isoflavone daidzein metabolism to ODMA. Individuals who do not have gut microbial environments that produce ODMA have less favorable cardiometabolic and cancer risk profiles. Urinary metabolomics profiles were evaluated in relation to ODMA metabotypes within and between individuals over time. Secondary analysis was conducted of data from the BEAN2 trial, which was a cross-over study of premenopausal women consuming six months on a high- and a low-soy diet, each separated by a 1-month washout period. In all of the 672 samples in the study, 66 of the 84 women had the same ODMA metabotype at seven or all eight time points. Two or four urine samples per woman were selected based on temporal metabotypes in order to compare within and across individuals. Metabolomics assays for primary metabolism and biogenic amines were conducted in 60 urine samples from 20 women. Partial least-squares discriminant analysis was used to compare metabolomics profiles.
Institute:George Mason University
Last Name:Frankenfeld
First Name:Cara
Address:4400 University Drive, Fairfax, VA 22030
Email:prof.frankenfeld@gmail.com
Phone:(206) 265-2563
Funding Source:Soy Health Research Program

Summary of all studies in project PR001218

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
Release
Date
VersionSamplesDownload
(* : Contains raw data)
ST001928 Metabolomics profiles of premenopausal women are different based on O-desmethylangolensin metabotype Homo sapiens George Mason University MS 2021-10-29 1 73 Not available
ST001929 Metabolomics profiles of premenopausal women are different based on O-desmethylangolensin metabotype (Part 2) Homo sapiens George Mason University MS 2021-11-02 1 61 Uploaded data (677.7M)*
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