Summary of project PR001224
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001224. The data can be accessed directly via it's Project DOI: 10.21228/M8H12N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001224 |
| Project DOI: | doi: 10.21228/M8H12N |
| Project Title: | Metabolomic, transcriptomic, and proteomic profiling of spontaneous macaque model for diabetes mellitus |
| Project Summary: | The prevalence of diabetes mellitus has been increasing for decades worldwide. To develop safe and potent therapeutics, insights into the mechanisms underlying its pathogenesis are urgently needed. We reported the multi-omics profiling of the liver and sera of both peripheral blood and hepatic portal vein blood from Macaca fascicularis with spontaneous diabetes mellitus with a chow diet. The other two groups of the monkeys fed with chow diet and high-sugar high-fat (HSHF) diet, respectively, were included for comparison. These multi-omics datasets can provide a comprehensive picture of the molecular changes caused by diabetes in primates. Analyses of various omics datasets revealed the alterations of high consistency. Correlation between transcripts and proteins derived from the same genes was observed across individuals for most genes, especially the ones of differential expression. As a result, we found that distinct patterns of the metabolome, proteome, and transcriptome between spontaneous diabetes and HSHF diet-induced diabetes compared with healthy individuals. |
| Institute: | Hong Kong Baptist University |
| Last Name: | Yang |
| First Name: | Zhu |
| Address: | OEW901, Oen Hall Building West Wing,, Ho Sin Hang Campus, Hong Kong Baptist University |
| Email: | yangzhu@gmail.com |
| Phone: | (+852)34115162 |
Summary of all studies in project PR001224
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001935 | Metabolomic profiling of spontaneous macaque model for diabetes mellitus | Macaca fascicularis | Xiamen University | MS | 2022-02-19 | 1 | 27 | Uploaded data (206.3M)* |
