Summary of project PR001274
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001274. The data can be accessed directly via it's Project DOI: 10.21228/M81Q4Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001274 |
| Project DOI: | doi: 10.21228/M81Q4Z |
| Project Title: | Chemoresistant Ovarian Cancer Global Metabolomics |
| Project Summary: | Chemoresistance remains the major barrier to effective ovarian cancer treatment. The molecular features and associated biological functions of this phenotype remain poorly understood. We developed carboplatin resistant cell line models using OVCAR5 and CaOV3 cell lines with the aim of identifying chemoresistance-specific molecular features. Mass spectrometry analysis was used to analyse the metabolome of these cell lines and was able to separate these populations based on their molecular features. It revealed signaling and metabolic perturbations in chemoresistant cell lines. A comprehensive analysis of a larger patient cohort, including advanced in vitro and in vivo models, promises to help better understand the molecular mechanisms of chemo-resistance and associated enhancement of migration and invasion. |
| Institute: | University of South Australia |
| Last Name: | Acland |
| First Name: | Mitchell |
| Address: | Cnr North Terrace and Morphett Street, Adelaide SA 5000 |
| Email: | mitch.acland@gmail.com |
| Phone: | 0425460869 |
Summary of all studies in project PR001274
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002010 | Chemoresistant Ovarian Cancer Global Metabolomics | Homo sapiens | University of South Australia | MS | 2021-12-22 | 1 | 22 | Uploaded data (2.2G)* |
