Summary of project PR001285
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001285. The data can be accessed directly via it's Project DOI: 10.21228/M8MD8N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001285 |
| Project DOI: | doi: 10.21228/M8MD8N |
| Project Title: | A targeted metabolomics study for assessing rodent thyroid toxicity |
| Project Summary: | The thyroid gland regulates various physiological mechanisms in mammals/humans, such as individual development, cell proliferation and differentiation. Thus, disorders can lead to diseases. In this study, we aimed to apply targeted metabolomics approach to investigate rodent thyroid toxicity. For this purpose, male Wistar rats have been exposed to a direct (6-propyl-2-thiouracil, PTU) and an indirect (phenytoin) thyroid toxicant, respectively. Thereby, two doses (low:5ppm for PTU and 300ppm for phenytoin , high: 50ppm for PTU and 2400ppm for phenytoin) and three exposure time phase (short: 2 weeks, long:4 weeks, and long+recovery: 4weeks+2weeks) were investigated, allowing insights into the modes of action during thyroid toxicity. Targeted metabolomics were applied to both liver and thyroid gland tissue. |
| Institute: | Helmholtz Centre for Environmental Research GmbH |
| Department: | Department of Molecular Systems biology |
| Laboratory: | Functional Metabolomics |
| Last Name: | Wang |
| First Name: | Zhipeng |
| Address: | Permoserstraße 15, Leipzig, Saxony, 04318, Germany |
| Email: | zhipeng.wang@ufz.de |
| Phone: | +49 341 235 1078 |
Summary of all studies in project PR001285
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002023 | A targeted metabolomics study for assessing rodent thyroid toxicity | Rattus norvegicus | Helmholtz Centre for Environmental Research | MS | 2022-12-20 | 1 | 149 | Uploaded data (45.7M)* |
