Summary of project PR001290
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001290. The data can be accessed directly via it's Project DOI: 10.21228/M8ZQ4B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001290 |
| Project DOI: | doi: 10.21228/M8ZQ4B |
| Project Title: | Maternal Hypoxemia and Oxidative Stress |
| Project Summary: | This project seeks to understand the metabolic consequences of gestational hypoxia on fetal, newborn, and adult plasma, arteries and other tissues using a sheep model of fetal growth restriction. Specifically we are interested testing the hypothesis that gestational hypoxia will result in discernable differences in glucose and lipid metabolism in tissues and plasma as well influence indicators of oxidative stress and inflammation. These studies aim to delineate pathways and biomarkers that help explain how hypoxia leads to the development of neonatal as well as adult-onset diseases associated with chronic hypoxia that are inter-related with fetal growth restriction. From a vascular perspective this includes cerebrovascular hemorrhage and pulmonary hypertension in the newborn, but more broadly it includes development of diseases later in life including diabetes, hypertension, and coronary artery disease. |
| Institute: | LOMA LINDA UNIVERSITY |
| Department: | Lawrence D. Longo, MD Center for Perinatal Biology |
| Laboratory: | Sean Wilson, Center for Perinatal Biology |
| Last Name: | Wilson |
| First Name: | Sean |
| Address: | 11234 Anderson Street, MC A582, Loma Linda, California 92350 |
| Email: | seanwilson@llu.edu |
| Phone: | 909-558-4325 |
| Funding Source: | WCMC Pilot Project (U24DK097154), P01HD083132 |
Summary of all studies in project PR001290
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002043 | Maternal Hypoxemia and Oxidative Stress | Ovis aries | Loma Linda University School of Medicine | MS | 2022-01-21 | 1 | 94 | Uploaded data (874.4M)* |
