Summary of project PR001290

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001290. The data can be accessed directly via it's Project DOI: 10.21228/M8ZQ4B This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001290
Project DOI:doi: 10.21228/M8ZQ4B
Project Title:Maternal Hypoxemia and Oxidative Stress
Project Summary:This project seeks to understand the metabolic consequences of gestational hypoxia on fetal, newborn, and adult plasma, arteries and other tissues using a sheep model of fetal growth restriction. Specifically we are interested testing the hypothesis that gestational hypoxia will result in discernable differences in glucose and lipid metabolism in tissues and plasma as well influence indicators of oxidative stress and inflammation. These studies aim to delineate pathways and biomarkers that help explain how hypoxia leads to the development of neonatal as well as adult-onset diseases associated with chronic hypoxia that are inter-related with fetal growth restriction. From a vascular perspective this includes cerebrovascular hemorrhage and pulmonary hypertension in the newborn, but more broadly it includes development of diseases later in life including diabetes, hypertension, and coronary artery disease.
Department:Lawrence D. Longo, MD Center for Perinatal Biology
Laboratory:Sean Wilson, Center for Perinatal Biology
Last Name:Wilson
First Name:Sean
Address:11234 Anderson Street, MC A582, Loma Linda, California 92350
Funding Source:WCMC Pilot Project (U24DK097154), P01HD083132

Summary of all studies in project PR001290

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST002043 Maternal Hypoxemia and Oxidative Stress Ovis aries Loma Linda University School of Medicine MS 2022-01-21 1 94 Uploaded data (874.4M)*