Summary of project PR001297
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001297. The data can be accessed directly via it's Project DOI: 10.21228/M82H7B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001297 |
| Project DOI: | doi: 10.21228/M82H7B |
| Project Title: | In vitro maturation of Toxoplasma gondii bradyzoites in human myotubes and their metabolomic characterization |
| Project Type: | characterization of in vitro T. gondii stages |
| Project Summary: | The apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections. Here, we developed a human myotube-based in vitro culture model of functionally mature tissue cysts. Metabolomic characterization of purified cysts reveals global changes that comprise increased levels of amino acids and decreased abundance of nucleobase- and tricarboxylic acid cycle-associated metabolites. In contrast to fast replicating tachyzoite forms of T. gondii these tissue cysts tolerate exposure to the aconitase inhibitor sodium fluoroacetate. |
| Institute: | Robert Koch-Institut |
| Last Name: | Blume |
| First Name: | Martin |
| Address: | Seestr. 10, Berlin, Berlin, 13353, Germany |
| Email: | blumem@rki.de |
| Phone: | +49 30 18754 2572 |
Summary of all studies in project PR001297
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002051 | The apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections. | Toxoplasma gondii | Robert Koch-Institute | MS | 2022-02-28 | 1 | 108 | Uploaded data (19.8G)* |
| ST002053 | Resistance to NaFAc of in vitro maturated Toxoplasma gondii bradyzoites in human myotubes. | Toxoplasma gondii | Robert Koch-Institute | MS | 2022-02-28 | 1 | 46 | Uploaded data (6.3G)* |
