Summary of project PR001366
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001366. The data can be accessed directly via it's Project DOI: 10.21228/M85115 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001366 |
| Project DOI: | doi: 10.21228/M85115 |
| Project Title: | Improvement of cognitive function by B. breve MCC1274 and elucidation of its mechanism of action |
| Project Summary: | Although many studies have suggested that probiotics could modulate various brain functions via the gut-brain axis, little is known about the mechanism underlying this process. We previously reported the beneficial effects of a probiotic strain, Bifidobacterium breve MCC1274, on cognitive function in preclinical and clinical studies. Recently, we showed that administration of this strain reduced amyloid-beta production, inhibited microglial activation, and suppressed inflammatory responses in the brains of APP knock-in (AppNL-G-F) mice. To elucidate the mechanism of action of this probiotic strain in an Alzheimer's disease-like model, we orally fed 3-month-old mice with B. breve MCC1274 or saline for 4 months and comprehensively investigated metabolites in plasma using CE-FTMS and LC-TOFMS. |
| Institute: | Morinaga milk industry CO., LTD. |
| Department: | Next generation science institute |
| Laboratory: | Frontier research section |
| Last Name: | Ohno |
| First Name: | Kazuya |
| Address: | 1-83 5-Chome Higashihara, Zama-city, Kanagawa-Pref. Japan |
| Email: | kazuya-oono443@morinagamilk.co.jp |
| Phone: | 81462523067 |
Summary of all studies in project PR001366
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002153 | Data from plasma metabolome analysis of APP-KI and Wild type mice treated with B. breve MCC1274 | Mus musculus | Morinaga milk industry CO., LTD. | MS | 2022-10-03 | 1 | 16 | Uploaded data (249.7K) |
