Summary of project PR001373
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001373. The data can be accessed directly via it's Project DOI: 10.21228/M87Q56 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001373 |
| Project DOI: | doi: 10.21228/M87Q56 |
| Project Title: | The study of metabolomics in tumor PMN-MDSCs |
| Project Summary: | Pathologically activated neutrophils (PMN), termed myeloid-derived suppressor cells (PMN-MDSCs), are major negative regulators of anti-tumor immunity. The mechanisms responsible for the pathological activation of neutrophils upon infiltration into tumors are not well defined, thus limiting the selective targeting of these cells. Tumor cells and immune cells engage in bi-directional manipulation of their respective metabolism, thereby altering cell function to facilitate tumor progression. Targeting the metabolism of responding immune cells can improve cancer treatment when combined with existing therapeutic strategies. Here, we investigated the role of metabolism in the immunoinhibitory actions of tumor PMN-MDSCs. |
| Institute: | The Wistar Institute |
| Last Name: | Nefedova |
| First Name: | Yulia |
| Address: | 3601 Spruce St, Philadelphia, PA 19104 |
| Email: | 215-495-6952 |
| Phone: | ynefedova@wistar.org |
Summary of all studies in project PR001373
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002160 | Global metabolomics analysis of neutrophils isolated from tumor | Mus musculus | The Wistar Institute | MS | 2023-05-05 | 1 | 10 | Uploaded data (2.1G)* |
