Summary of project PR001384

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001384. The data can be accessed directly via it's Project DOI: 10.21228/M8TH8J This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001384
Project DOI:doi: 10.21228/M8TH8J
Project Title:Effect of external high-dose rate radiation on mouse biofluid metabolomics
Project Summary:In the event of an improvised nuclear device (IND), a complex IR exposure will occur consisting of both low (LDR) and high-dose rates (HDR). We have previously addressed LDR exposures from internal emitters or externally deposited radionuclides on biofluid small molecule signatures, but further research on the HDR component is required. Here, we exposed 8 − 10 week old male C57BL/6 mice to a cumulative dose of 3 Gy using a reference dose rate of 0.7 Gy/min or a HDR of 7 Gy/sec, collected urine and serum at 1 and 7 d, then compared the metabolite signatures using a untargeted (urine) approache with liquid chromatography mass spectrometry platforms.
Institute:Georgetown University
Last Name:Pannkuk
First Name:Evan
Address:3970 Reservoir Rd, NW New Research Building E504
Email:elp44@georgetown.edu
Phone:2026875650
Publications:https://www.mdpi.com/2218-1989/12/6/520

Summary of all studies in project PR001384

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST002175 Effect of external high-dose rate radiation on mouse biofluid metabolomic signatures Mus musculus Georgetown University MS* 2023-06-01 1 67 Uploaded data (17.3G)*
ST002176 Effect of external high-dose rate radiation on mouse biofluid metabolomic signatures (neg) Mus musculus Georgetown University MS* 2023-06-01 1 67 Uploaded data (17.1G)*
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