Summary of project PR001447
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001447. The data can be accessed directly via it's Project DOI: 10.21228/M8PH7X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001447 |
| Project DOI: | doi: 10.21228/M8PH7X |
| Project Title: | Multi-omic analysis reveals bacteria may have a role in dental erosion |
| Project Type: | Research Study |
| Project Summary: | NMR was performed on 11 saliva samples; 5 from participants classified as having dental erosion and 6 from healthy control participants with no dental erosion to assess the differences in metabolome between the two groups. NMR analysis alone revealed no significant differences between the dental erosion and healthy controls. However, bacterial mRNA sequencing of the oral microbiome from the same saliva samples was performed and the bacterial gene expression profiles was correlated to metabolite concentrations in the groups. The dental erosion group had strong correlations between metabolites associated with protein degradation and amino acid fermentation (formate, butyrate, propionate, 5-aminopentanoate, acetate, glycine, phenylalanine, dimethyl sulfone) and increased activity of species including 4 Prevotella species, Actinomyces graevenitzii, Tannerella species, and 2 Selenomas species, to name a few. Whereas in the healthy control group, the only positive correlations between metabolite concentrations and bacterial activity was for urea and 5-aminopentanoate; urea was positively correlated with Aggregatibacter actinomycetecomytans, Lysinibacillus fusiformis, and Veillonella tobetsuensis, and 5-aminopentanoate was positively correlated with 3 different Leptotrichia species, Streptococcus parasanguinis, and 2 Prevotella species. |
| Institute: | King's College London |
| Department: | Centre for Host Microbiome Interactions |
| Last Name: | Cleaver |
| First Name: | Leanne |
| Address: | Floor 17, Tower Wing, Guy's Hospital, King's College London, Great Maze Pond |
| Email: | leanne.cleaver@kcl.ac.uk |
| Phone: | 07464626438 |
Summary of all studies in project PR001447
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002265 | Multi-omic analysis reveals bacteria may have a role in dental erosion | Homo sapiens | King's College London | NMR | 2022-09-05 | 1 | 34 | Uploaded data (26.4M)* |
