Summary of project PR001451
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001451. The data can be accessed directly via it's Project DOI: 10.21228/M85H8N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001451 |
| Project DOI: | doi: 10.21228/M85H8N |
| Project Title: | Targeted plasma metabolomics in pediatric NAFLD patients |
| Project Summary: | Several adult omics studies have been conducted to understand the pathophysiology of nonalcoholic fatty liver disease (NAFLD). However, the histological features of children are different from those of adults, and the onset and progression of pediatric NAFLD are not fully understood. In this study, we aimed to evaluate the metabolome profile and metabolic pathway changes associated with pediatric NAFLD to elucidate its pathophysiology. We analyzed the metabolic profiles of healthy control, lean NAFLD, overweight control and overweight NAFLD groups of children and adolescent participants (n = 165) by assessing plasma samples, and identified 18 NAFLD-specific metabolic features and metabolic changes in lipid, glutathione-related amino acid, and branched-chain amino acid metabolism by comparing control and NAFLD group in pediatric population with overweight. Metabolome changes in the plasma of pediatric patients with NAFLD are associated with the pathophysiology of the disease and can be utilized as a less-invasive approach to diagnose the disease. |
| Institute: | Seoul National University College of Medicine and Hospital |
| Department: | Department of Clinical Pharmacology and Therapeutics |
| Last Name: | Chae |
| First Name: | Woori |
| Address: | 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea |
| Email: | yunus@snu.ac.kr |
| Phone: | 82-2-740-8905 |
| Funding Source: | National Research Foundation (NRF) grant funded by the Korea government (Ministry of Science and ICT) [grant number NRF-2019R1F1A1057588] |
Summary of all studies in project PR001451
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002269 | Targeted plasma metabolomics in pediatric NAFLD patients | Homo sapiens | Seoul National University College of Medicine and Hospital | MS | 2023-08-07 | 1 | 174 | Uploaded data (4.6G)* |
