Summary of project PR001583
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001583. The data can be accessed directly via it's Project DOI: 10.21228/M82X4B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001583 |
| Project DOI: | doi: 10.21228/M82X4B |
| Project Title: | Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation |
| Project Type: | lipidomics analysis |
| Project Summary: | Phospholipase A2 group V (PLA2G5) is a secretory and Ca2+-dependent lipolytic enzyme and is inducible during several pathologic conditions. However, it has been unknown how PLA2G5 plays a role in sepsis. To study the role of PLA2G5 in sepsis, we performed lipidomics analysis of plasma and tissues from LPS-injected mice with or without PLA2G5 blockade. Here, we showed that PLA2G5 is involved in the production of fatty acids such as oleic acid and linoleic acid, lysophospholipids such as lysophosphatidic acid, lysophosphatidylcholine, lysophatidylethanolamine, and lysophosphatidylserine species, and metabolites derived from polyunsaturated fatty acids such as arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and linoleic acids during sepsis. Thus, PLA2G5 regulates selective lipid pathways during sepsis. |
| Institute: | University of Chicago |
| Department: | Pritzker School of Molecular Engineering |
| Laboratory: | Chevrier lab |
| Last Name: | Takahama |
| First Name: | Michihiro |
| Address: | 900 E 57th St,, Chicago, Illinois, 60637, USA |
| Email: | mtakahama@uchicago.edu |
| Phone: | 7732302766 |
Summary of all studies in project PR001583
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002455 | Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation | Mus musculus | University of Chicago | MS | 2024-01-23 | 1 | 64 | Uploaded data (1.4M)* |
