Summary of project PR001612
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001612. The data can be accessed directly via it's Project DOI: 10.21228/M8BB1T This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001612 |
| Project DOI: | doi: 10.21228/M8BB1T |
| Project Title: | Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP) |
| Project Summary: | Nutritional deprivation occurring in most preterm infants postnatally, can induce hyperglycemia, a significant and independent risk factor for suppressing physiological retinal vascularization (Phase I retinopathy of prematurity (ROP)), leading to compensatory but pathological neovascularization. Amino acid supplementation reduces retinal neovascularization in mice. Little is known about amino acid contribution to Phase I ROP. Significant changes in retinal amino acids (including most decreased L-leucine, L-isoleucine and L-valine) were found in mice modeling hyperglycemia-associated Phase I ROP, and parenteral (i.p.) L-isoleucine suppressed physiological retinal vascularization. In premature infants, severe ROP was associated with a higher mean intake of parenteral versus enteral amino acids in the first two weeks of life after adjustment for treatment group, gestational age at birth, birth weight and sex. The number of days with parenteral amino acids support independently predicted severe ROP. Further understanding and modulating amino acids may help improve nutritional intervention and prevent Phase I ROP |
| Institute: | Boston Childrens Hospital |
| Last Name: | Fu |
| First Name: | Zhongjie |
| Address: | 1 Blackfan Circle, Boston, MA 02114 |
| Email: | Zhongjie.Fu@childrens.harvard.edu |
| Phone: | 617-919-2534 |
Summary of all studies in project PR001612
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002497 | Postnatal hyperglycemia alters amino acid profile in retinas | Mus musculus | Boston Childrens Hospital | MS | 2023-03-22 | 1 | 12 | Uploaded data (300.6M)* |
