Summary of project PR001632
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001632. The data can be accessed directly via it's Project DOI: 10.21228/M8RB05 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001632 |
| Project DOI: | doi: 10.21228/M8RB05 |
| Project Title: | Effectors enabling adaptation to mitochondrial complex I loss in Hürthle cell carcinoma |
| Project Summary: | Oncocytic (Hürthle cell) carcinoma of the thyroid (HCC) is genetically characterized by complex I mitochondrial DNA mutations and widespread chromosomal losses. In this project, RNA-seq and metabolomics were used to identify candidate molecular effectors activated by these genetic drivers. |
| Institute: | Broad Institute of MIT and Harvard |
| Department: | Metabolomics Platform |
| Last Name: | Clish |
| First Name: | Clary |
| Address: | 415 Main Street, Cambridge, MA, 02142, USA |
| Email: | clary@broadinstitute.org |
| Phone: | 617-714-7654 |
| Funding Source: | Inflammatory Bowel Disease Grant DK043351, Boston Area Diabetes and Endocrinology Research Center (BADERC) Award DK057521, the Bertarelli Rare Cancers Fund, the Elizabeth and Michael Ruane family, 2T32DK007028-46, NIH K00CA212468, NIH K12CA087723, and the Howard Hughes Medical Institute |
| Publications: | submitted |
| Contributors: | Raj K. Gopal, Venkata R. Vantaku, Apekshya Panda, Bryn Reimer, Sneha Rath, Tsz-Leung To, Adam S. Fisch, Murat Cetinbas, Maia Livneh, Michael J. Calcaterra, Benjamin J. Gigliotti, Kerry Pierce, Clary B. Clish, Dora Dias-Santagata, Peter M. Sadow, Lori J. Wirth, Gilbert H. Daniels, Ruslan I. Sadreyev, Sarah E. Calvo, Sareh Parangi, Vamsi K. Mootha |
Summary of all studies in project PR001632
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002536 | Effectors enabling adaptation to mitochondrial complex I loss in Hürthle cell carcinoma | Homo sapiens | Broad Institute of MIT and Harvard | MS | 2023-04-17 | 1 | 48 | Uploaded data (25G)* |
