Summary of project PR001761
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001761. The data can be accessed directly via it's Project DOI: 10.21228/M83139 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001761 |
| Project DOI: | doi: 10.21228/M83139 |
| Project Title: | Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy |
| Project Summary: | Mounting evidence supports an instructive role for metabolism in stem cell fate decisions. However, much is yet unknown about how fetal metabolism changes during mammalian development and how altered maternal metabolism shapes fetal metabolism. Here, we present a descriptive atlas of in vivo fetal murine metabolism during mid-to-late gestation in normal and diabetic pregnancy. Using 13C-glucose and LC-MS, we profiled the metabolism of fetal brains, hearts, livers, and placentas harvested from pregnant dams between embryonic days (E)10.5 and 18.5. Comparative analysis of our large metabolomics dataset revealed metabolic features specific to fetal tissues developed under a hyperglycemic environment as well as metabolic signatures that may denote developmental transitions during euglycemic development. We observed sorbitol accumulation in fetal tissues and altered neurotransmitter levels in fetal brains isolated from dams with maternal hyperglycemia. Tracing 13C-glucose revealed disparate nutrient sourcing in fetuses depending on maternal glycemic states. Regardless of glycemic state, histidine-derived metabolites accumulated during late development in fetal tissues and maternal plasma. Our rich dataset presents a comprehensive overview of in vivo fetal tissue metabolism and alterations occurring as a result of maternal hyperglycemia. |
| Institute: | University of California, Los Angeles |
| Department: | Biological Chemistry |
| Laboratory: | Heather Christofk |
| Last Name: | Matulionis |
| First Name: | Nedas |
| Address: | 615 Charles E Young Drive South Los Angeles, CA, 90095 |
| Email: | nmatulionis@mednet.ucla.edu |
| Phone: | 3102060163 |
Summary of all studies in project PR001761
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002814 | Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy | Mus musculus | University of California, Los Angeles | MS | 2023-12-08 | 1 | 514 | Uploaded data (30.7G)* |
| ST002878 | Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy. Dynamic Labelling experiment. | Mus musculus | University of California, Los Angeles | MS | 2023-12-08 | 1 | 173 | Uploaded data (9.8G)* |
