Summary of project PR001765
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001765. The data can be accessed directly via it's Project DOI: 10.21228/M8K128 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001765 |
| Project DOI: | doi: 10.21228/M8K128 |
| Project Title: | Smoking Induced Gut Microbial Dysbiosis Mediates Cancer Progression Through Adaptive Immune System Modulation |
| Project Summary: | Cigarette smoke exposure (CSE), either through active smoking or secondhand smoke, increases the risk for a plethora of cancers. Studies have estimated that one in three cancer deaths is associated with cigarette smoke exposure. However, despite ongoing research on numerous carcinogens, the underlying mechanism(s) remain poorly understood. Recent evidence indicates that the gut microbiome can influence cancer progression by immune system modulation. Since CSE alters the gut microbiome, we hypothesized that the gut microbiome serves as a causative link between smoking and cancer growth. Through a combination of rigorous syngeneic animal models and fecal microbiome transplantation studies, we establish an essential role for smoke-induced dysbiosis in cancer growth. Using Flow cytometric analysis of tumor specimens and experiments in Rag 1 KO and CD8 KO, we demonstrate that smoke induced tumor growth requires functional adaptive immunity. We further characterized the unique gut microbial and metabolomic signatures induced by CSE using high throughput 16s rRNA sequencing and mass spectrometric techniques. Finally, utilizing gut microbial ablation strategies with broad and narrow-spectrum antibiotics, we demonstrate the reversal of phenotypic effects of CSE and present a novel actionable target to mitigate CSE-induced tumor promotion. |
| Institute: | University of Alabama, Birmingham |
| Last Name: | Vikas |
| First Name: | Dudeja |
| Address: | 1808 7th Avenue South Boshell Building- Suite 573 Birmingham, AL 35294 |
| Email: | vdudeja@uabmc.edu |
| Phone: | 205 975 7836 |
Summary of all studies in project PR001765
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002823 | Smoking Induced Gut Microbial Dysbiosis Mediates Cancer Progression Through Adaptive Immune System Modulation | Mus musculus | University of Alabama, Birmingham | MS* | 2025-02-21 | 1 | 29 | Uploaded data (2.2G)* |
