Summary of project PR001786
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001786. The data can be accessed directly via it's Project DOI: 10.21228/M8VB1G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001786 |
| Project DOI: | doi: 10.21228/M8VB1G |
| Project Title: | MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer |
| Project Summary: | Advanced prostate cancers are treated with therapies targeting the androgen receptor (AR) signaling pathway. While many tumors initially respond to AR inhibition, nearly all develop resistance. It is critical to understand how prostate tumor cells respond to AR inhibition in order to exploit therapy-induced phenotypes prior to the outgrowth of treatment-resistant disease. Here, we comprehensively characterize the effect of AR blockade on prostate cancer metabolism using transcriptomics, metabolomics and bioenergetics approaches. The metabolic response to AR inhibition is defined by reduced glycolysis, robust elongation of mitochondria, and increased reliance on mitochondrial oxidative metabolism. We establish DRP1 activity and MYC signaling as mediators of AR blockade-induced metabolic phenotypes. Rescuing DRP1 phosphorylation after AR inhibition restores mitochondrial fission, while rescuing MYC restores glycolytic activity and prevents sensitivity to complex I inhibition. Our study provides new insight into the regulation of treatment-induced metabolic phenotypes and vulnerabilities in prostate cancer. |
| Institute: | University of California, Los Angeles |
| Department: | Biological Chemistry |
| Laboratory: | Heather Christofk |
| Last Name: | Matulionis |
| First Name: | Nedas |
| Address: | 615 Charles E Young Dr S, BSRB 354-05 |
| Email: | nmatulionis@mednet.ucla.edu |
| Phone: | 3102060163 |
Summary of all studies in project PR001786
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002852 | MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer | Mus musculus | University of California, Los Angeles | MS | 2023-09-11 | 1 | 16 | Uploaded data (1G)* |
| ST002863 | Metabolic profiling and glucose tracing in naive and Enzalutamide-treated 16D prostate cancer cells | Homo sapiens | University of California, Los Angeles | MS | 2023-09-19 | 1 | 14 | Uploaded data (1.7G)* |
| ST002864 | Metabolic profiling, glucose tracing and glutamine tracing in naive and Enzalutamide-treated 16D prostate cancer cells expressing RFP or MYC | Homo sapiens | University of California, Los Angeles | MS | 2023-09-19 | 1 | 27 | Uploaded data (6.5G)* |
| ST002865 | Metabolic profiling, glucose tracing and glutamine tracing in 16D prostate cancer cells treated with vehicle, AR inhibitor Enzalutamide, AR inhibitor Apalutamide, or AR degrader/PROTAC ARCC-4 | Homo sapiens | University of California, Los Angeles | MS | 2023-09-19 | 1 | 27 | Uploaded data (6.4G)* |
