Summary of project PR001802
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001802. The data can be accessed directly via it's Project DOI: 10.21228/M8SD9K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001802 |
| Project DOI: | doi: 10.21228/M8SD9K |
| Project Title: | Metabolic alterations during cachexia in pancreatic ductal adenocarcinoma (PDAC). |
| Project Type: | MS qualitative analysis |
| Project Summary: | Cachexia is a multi-organ pathological state characterized by physical wasting and tissue catabolism. It occurs in 80% of pancreatic cancer patients, and to date there are no preventative or early detection methods. Cachexia leads to limited tolerance to anti-cancer therapy and is a lethal disease. Here, we have characterized a mouse model of cachexia in pancreatic ductal adenocarcinoma (PDAC) in order to better understand disease progression: the physiology across stages of cachexia in the model recaptures well the progressive disease in humans. We present the first-of-its-kind systemic metabolomic analysis across cachectic stages in the tumor, interstitial fluid, liver, fats, muscles, and blood plasma. The primary source of variation in the data is the tissue type, indicating that each tissue has a unique metabolome and trajectory across cachexia stages. We use mathematical modeling to identify metabolites that may be participating in cross-tissue networks in pre-, early-, and late-stage cachexia. Pathway analysis shows a particular emphasis on lipid alterations. Strikingly, we find systemic metabolic changes prior to weight loss in these animals, and use feature selection algorithms to identify potential predictive markers of cachexia progression. Overall, we hope our work is a valuable resource for the field and will lay the foundation for metabolic insights into pancreatic cancer cachexia and its prevention and treatment. |
| Institute: | Boston Children's Hospital, Harvard Medical School |
| Last Name: | Kalaany |
| First Name: | Nada |
| Address: | 3 Blackfan Circle |
| Email: | Nada.Kalaany@childrens.harvard.edu |
| Phone: | 617-919-4896 |
Summary of all studies in project PR001802
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002881 (Available on 2026-06-01) | Metabolic profiling plasma in mice during cachexia. | Mus musculus | Boston Children's Hospital, Harvard Medical School | MS* | - | - | 162 | Not available |
| ST002882 (Available on 2026-06-01) | Metabolic profiling interstitial fluid in mice during cachexia. | Mus musculus | Boston Children's Hospital, Harvard Medical School | MS* | - | - | 94 | Not available |
| ST002883 (Available on 2026-06-01) | Metabolic profiling brown adipose tissue in mice during cachexia. | Mus musculus | Boston Children's Hospital, Harvard Medical School | MS* | - | - | 54 | Not available |
| ST002884 (Available on 2026-02-01) | Metabolic profiling gonadal white adipose tissue in mice during cachexia. | Mus musculus | Boston Children's Hospital, Harvard Medical School | MS* | - | - | 54 | Not available |
| ST002885 (Available on 2026-06-01) | Metabolic profiling gastrocnemius tissue in mice during cachexia. | Mus musculus | Boston Children's Hospital, Harvard Medical School | MS* | - | - | 54 | Not available |
| ST002886 (Available on 2026-06-01) | Metabolic profiling Inguinal white adipose tissue in mice during cachexia. | Mus musculus | Boston Children's Hospital, Harvard Medical School | MS* | - | - | 54 | Not available |
| ST002887 (Available on 2026-06-01) | Metabolic profiling liver tissue in mice during cachexia. | Mus musculus | Boston Children's Hospital, Harvard Medical School | MS* | - | - | 54 | Not available |
| ST002888 (Available on 2026-06-01) | Metabolic profiling Pancreas tissue in mice during cachexia. | Mus musculus | Boston Children's Hospital, Harvard Medical School | MS* | - | - | 54 | Not available |
| ST002889 (Available on 2026-06-01) | Metabolic profiling Quadriceps tissue in mice during cachexia. | Mus musculus | Boston Children's Hospital, Harvard Medical School | MS* | - | - | 54 | Not available |
| ST002904 (Available on 2026-06-01) | Metabolic profiling Soleus tissue in mice during cachexia. | Mus musculus | Boston Children's Hospital, Harvard Medical School | MS* | - | - | 114 | Not available |
