Summary of project PR001808
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001808. The data can be accessed directly via it's Project DOI: 10.21228/M80X4Q This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001808 |
| Project DOI: | doi: 10.21228/M80X4Q |
| Project Title: | Rumenomics: Evaluation of rumen metabolites content on phenotypical features of sheep |
| Project Type: | Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectroscopy (UPLC-MS/MS) |
| Project Summary: | Study the link between the gut microbiome and glycosaminoglycan (GAG) production and turnover in synovial joint tissues using cell culture, tissue biomechanics, and studies in mice and sheep. Gut-Joint Axis. Here we evaluate the functional linkages between 510 metabolites collected from rumen compartment in sheep and identified from Metabolomics with phenotypic features such as weight, sex, age and breed. The associations between metabolites and phenotypic features were established by principal component analysis, partial least squares regression, univariate linear modeling and multiple hypothesis testing. With these results, we extract association insights that reveal the most influential metabolites per each phenotypic feature. |
| Institute: | Purdue University |
| Department: | Biomedical Engineering - Veterinary Clinical Sciences |
| Last Name: | Munoz-Briones |
| First Name: | Javier |
| Address: | 610 Purdue Mall, West Lafayette, IN 47907 |
| Email: | munoz99@purdue.edu |
| Phone: | 7657469102 |
| Funding Source: | DARPA |
| Contributors: | Smrutiti Jena, Brendan Ball, Tim Lescun, Deva Chan, Doug Brubaker, Javier Munoz Briones |
Summary of all studies in project PR001808
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002908 | Rumenomics: Evaluation of rumen metabolites content on phenotypical features of sheep | Ovis aries | Purdue University | MS | 2025-09-30 | 1 | 16 | Uploaded data (7.4M) |
