Summary of project PR001897
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001897. The data can be accessed directly via it's Project DOI: 10.21228/M8HH8R This work is supported by NIH grant, U2C- DK119886.
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| Project ID: | PR001897 |
| Project DOI: | doi: 10.21228/M8HH8R |
| Project Title: | Defective mitochondria remodelling in B cells leads to an aged immune response |
| Project Summary: | The germinal centre (GC) reaction requires a unique bioenergetic supply. Although mitochondria are remodelled upon antigen stimulation, mitochondrial function in B cells is still poorly understood. To gain a better understanding of the role of mitochondria in B cell function, we generated mice that lack, specifically in B cells, Tfam, a transcription factor necessary for mitochondrial biogenesis. Tfam knock-out (KO) mice displayed a blockage of the GC reaction and established an immune response featured by the differentiation of activated B cells towards memory B cells and aged-related B cells, hallmarks of an aged immune response. Unexpectedly, GC blockage in Tfam KO mice did not cause defects in the bioenergetic supply, but this phenotype was associated with a defect in the remodelling of the lysosomal compartment in B cells. Therefore, these results may describe a new mitochondrial function for antigen presentation during the GC reaction, the abrogation of which may be the basis of an aged immune response. |
| Institute: | Consejo Superior de Investigaciones Científicas |
| Last Name: | Martínez-Martín |
| First Name: | Nuria |
| Address: | Calle Nicolás Cabrera, 1, Madrid, Madrid, 28049, Spain |
| Email: | nmartinez@cbm.csic.es |
| Phone: | 0034-911964517 |
Summary of all studies in project PR001897
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003047 | Defective mitochondria remodelling in B cells leads to an aged immune response | Mus musculus | Consejo Superior de Investigaciones Científicas | MS | 2024-02-05 | 1 | 6 | Uploaded data (415.2M)* |
