Summary of project PR001994
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001994. The data can be accessed directly via it's Project DOI: 10.21228/M8014R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001994 |
| Project DOI: | doi: 10.21228/M8014R |
| Project Title: | A study of 9 common breath VOCs in 504 healthy subjects using PTR-TOF-MS |
| Project Summary: | This study utilized Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) to analyze the exhaled breath profiles of 504 healthy adults, focusing on nine common breath volatile organic compounds (VOCs): acetone, acetaldehyde, acetonitrile, ethanol, isoprene, methanol, propanol, phenol, and toluene. The concentrations of these VOCs exhibited log normal distributions, with distinct differences observed based on different gender, age, and smoking history groups. Male group showed higher average VOC concentrations of acetaldehyde, acetonitrile, isoprene, and toluene. Age-related effects were evident, particularly in propanol and methanol, whose concentrations increased significantly with age. Smoking history also influenced VOC concentrations, with significant differences among non-smokers, current smokers, and ex-smokers. Ex-smokers demonstrated lower VOC levels than current smokers, indicating a normalization post-smoking cessation. Positive correlations were identified between breath VOC concentrations and years of smoking. The study enhances understanding of demographic influences on exhaled VOC profiles, contributing valuable insights for potential applications in health monitoring and clinical diagnosis. The use of PTR-MS was crucial for real-time VOC measurement, offering advantages over conventional methods. The research lays a foundation for future developments in non-invasive disease detection. The results highlight the potential of breath analysis as a valuable tool for health assessment. |
| Institute: | Breathonix Pte Ltd |
| Last Name: | |
| First Name: | Zihao |
| Address: | 83 Science Park, #02-01A, The Curie, Singapore, Singapore, Singapore, 118258, Singapore |
| Email: | zihao@breathonix.com |
| Phone: | 87805084 |
Summary of all studies in project PR001994
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003200 | A study of 9 common breath VOCs in 504 healthy subjects using PTR-TOF-MS | Homo sapiens | Breathonix Pte Ltd | MS | 2025-05-08 | 1 | 504 | Uploaded data (2.7G)* |
