Summary of project PR002031
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002031. The data can be accessed directly via it's Project DOI: 10.21228/M83529 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002031 |
| Project DOI: | doi: 10.21228/M83529 |
| Project Title: | Diabetic ischaemic cardiomyopathy: Characterising the left ventricular myocardial molecular profile in advanced human heart failure |
| Project Type: | Human heart failure left ventricular myocardial multi-omics study across multiple disease phenotypes |
| Project Summary: | Ischaemic cardiomyopathy (ICM) is the most common cause of heart failure (HF) and often coexists with diabetes mellitus (DM). Yet, their combined effects are seldom investigated and are poorly understood. Herein, we performed multi-omic analyses of end-stage ICM with DM (ICM-DM) against ICM-No DM, non-ischaemic (dilated) cardiomyopathy with DM (NICM-DM), NICM-No DM, and healthy age-matched donors (AMD). Tissue was sourced from pre-mortem human left ventricular myocardium. Though fatty acid oxidation (FAO) proteins were down-regulated in ICM-DM relative to AMD and other HF, the unique ICM-DM down-regulation of acylcarnitines, perilipin, and ketone body, amino acid, and glucose metabolising proteins indicated FAO may not be entirely impaired. Oxidative phosphorylation appeared reduced in HF but exacerbated in ICM-DM, consistent with purportedly increased oxidative stress. Extracellular matrix proteins including collagens were up-regulated principally in ICM-DM despite the absence of macroscopic scar tissue. These findings were supported histologically and in metabolomic and RNA sequencing analyses. |
| Institute: | The University of Sydney |
| Last Name: | Hunter |
| First Name: | Benjamin |
| Address: | John Hopkins Dr, Camperdown, NSW, 2006, Australia |
| Email: | benjamin.hunter@sydney.edu.au |
| Phone: | +61422525639 |
Summary of all studies in project PR002031
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003274 | Metabolomics analysis within healthy donors and end-stage heart failure with a focus on ischaemic cardiomyopathy with diabetes | Homo sapiens | University of Sydney | MS | 2025-05-06 | 1 | 77 | Uploaded data (71.1M)* |
| ST003275 | Lipidomics analysis within healthy donors and end-stage heart failure with a focus on ischaemic cardiomyopathy with diabetes | Homo sapiens | University of Sydney | MS | 2025-05-06 | 1 | 75 | Uploaded data (103.3G)* |
