Summary of project PR002114
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002114. The data can be accessed directly via it's Project DOI: 10.21228/M8C54J This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002114 |
| Project DOI: | doi: 10.21228/M8C54J |
| Project Title: | The “metabolic fingerprint” of cytotoxic gold drugs in cancer cells disclosed by NMR |
| Project Type: | NMR-based metabolomics |
| Project Summary: | NMR metabolomics is a powerful tool for characterizing changes in cancer cell metabolism induced by drug treatment. Here, this approach is used to elucidate the effects of five cytotoxic gold compounds in A2780 human ovarian cancer cells. Namely, two close analogues of auranofin (AF), AFCl and AFI, a gold(I) triphenylphosphine complex, (Ph3P)AuI, and two representative gold(III) compounds, AuL12 and Aubipyc, were investigated. Interestingly, the three gold(I) compounds were found to induce similar and pronounced metabolic changes in the lysates and growth media, whereas the two gold(III) compounds induced only minor changes. The results are analysed and discussed in the context of the existing knowledge on gold-based anticancer drugs, their modes of action and their effects on cellular metabolism. To this end, we included in our dataset four additional gold-based drugs, already individually investigated in previous studies. Statistical tools are used to highlight similarities and differences between the various compounds. Attempts are made to establish well-defined structure-function relationships within the set of tested gold compounds |
| Institute: | University of Florence |
| Last Name: | GHINI |
| First Name: | VERONICA |
| Address: | via Luigi Sacconi 6 |
| Email: | ghini@cerm.unifi.it |
| Phone: | 03922800462 |
Summary of all studies in project PR002114
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003416 | The “metabolic fingerprint” of cytotoxic gold drugs in cancer cells disclosed by NMR | Homo sapiens | University of Florence | NMR | 2025-02-17 | 1 | 259 | Uploaded data (733.5M)* |
