Summary of project PR002222
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002222. The data can be accessed directly via it's Project DOI: 10.21228/M8DF9H This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002222 |
| Project DOI: | doi: 10.21228/M8DF9H |
| Project Title: | Comparative metabolomics of a-Synuclein expression in Drosophila melanogaster |
| Project Type: | untargeted metabolomics |
| Project Summary: | Drosophila melanogaster, or the fruit fly, is a great model system for motor disorders such as Parkinson’s disease (PD). However, Drosophila does not express in vivo the α-Synuclein (αSyn) protein, the chief molecular hallmark of PD. Therefore, αSyn-expression in Drosophila and profiling the associated metabolomic changes are crucial in elucidating molecular mechanism of PD using Drosophila models. Using comparative global metabolomics and integrated cheminformatics for high coverage, this study aims to provide fundamental metabolomics data specific to αSyn expression in Drosophila melanogaster. Fly heads and body compartments were analyzed separately, with an interest to probe the gut-brain axis potentially involved. |
| Institute: | Columbia University |
| Department: | Department of Environmental Health Sciences |
| Laboratory: | The Miller Lab |
| Last Name: | Lai |
| First Name: | Yunjia |
| Address: | 630 West 168th Street, P&S 16-421, New York, NY 10032 |
| Email: | yunjia.lai@outlook.com |
| Phone: | 9194805489 |
| Funding Source: | National Institutes of Health |
Summary of all studies in project PR002222
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003593 (Available on 2026-06-30) | Metabolomics of Drosophila melanogaster with a-Synuclein expression (head) | Drosophila melanogaster | Columbia University | MS* | - | - | 26 | Not available |
| ST003594 | Metabolomics of Drosophila melanogaster with a-Synuclein expression (body) | Drosophila melanogaster | Columbia University | MS* | 2026-01-02 | 1 | 26 | Uploaded data (7.5G)* |
