Summary of project PR002229

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002229. The data can be accessed directly via it's Project DOI: 10.21228/M8H822 This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR002229
Project DOI:doi: 10.21228/M8H822
Project Title:Rapid modulation of gut microbiota composition by hypothalamic circuits in mice
Project Type:Metabolomics
Project Summary:Whether the hypothalamus is able to influence gut microbiota composition remains enigmatic. Here, we present a proof-of-concept study designed to unravel this challenging question. To this aim, we centrally administered leptin or ghrelin to male mice. Subsequently, we conducted microbiota composition analysis throughout the gut using 16S rRNA gene sequencing. Our results showed that these brain interventions significantly changed the gut microbiota in an anatomical and short-term (two to four hours) fashion. Metabolomics analysis was performed on the intestinal content of the duodenum 4h after leptin injection, revealing changed metabolite levels.
Institute:University of Luebeck
Department:Bioanalytic Core Facility
Last Name:Inderhees
First Name:Julica
Address:Ratzeburger Allee 34b, 23568 Luebeck
Email:julica.inderhees@uni-luebeck.de
Phone:+4945131012805
Funding Source:European Research Council ERC-Synergy-Grant-2019-WATCH No. 810331
Contributors:Míriam Toledo, Sara Martínez-Martínez, Rubén Nogueiras, Marc Claret

Summary of all studies in project PR002229

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
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(* : Contains raw data)
ST003601 Rapid modulation of gut microbiota composition by hypothalamic circuits in mice Mus musculus University of Luebeck MS 2025-02-27 1 42 Uploaded data (5.4G)*
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