Summary of project PR002240
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002240. The data can be accessed directly via it's Project DOI: 10.21228/M8325D This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002240 |
| Project DOI: | doi: 10.21228/M8325D |
| Project Title: | Lipidomic analysis of human regulatory T cells. |
| Project Summary: | Regulatory T cells (Tregs) are characterized by stable FOXP3 expression and controlling immune response by suppressive activity. Unique metabolic properties of Tregs are shown such as reduced glycolysis and increased oxidative phosphorylation. We have combined transcriptomics, metabolomics and lipidomics to dissect metabolic dynamics of Tregs upon activation. Combined metabolomic and lipidomic analysis showed that freshly isolated Tregs have unique metabolomic property, on the other hand, activated Tregs have unique lipidomic property. Interestingly, activated Tregs contained omega-3 polyunsaturated fatty acids (PUFA) enriched diglycerides and triglycerides. |
| Institute: | The Jikei University School of Medicine |
| Last Name: | Sato |
| First Name: | Yohei |
| Address: | 3-25-8 Nishishinbashi, Minato-ku, Tokyo, 1058461, Japan |
| Email: | yoheisatoo@gmail.com |
| Phone: | +81-3-3433-1111 |
Summary of all studies in project PR002240
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003627 | Lipidomic analysis of human regulatory T cells. | Homo sapiens | Jikei University School of Medicine | MS | 2025-06-02 | 1 | 12 | Not available |
