Summary of project PR002259
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002259. The data can be accessed directly via it's Project DOI: 10.21228/M8MV7R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002259 |
| Project DOI: | doi: 10.21228/M8MV7R |
| Project Title: | Human adenovirus serotype 5 infection dysregulates cysteine, purine, and unsaturated fatty acid metabolism in fibroblasts |
| Project Summary: | Over 100 types of adenoviruses exist across 7 species, with about 50 known to infect humans. Human adenoviruses overtake the DNA replication machinery of the infected host, rewiring mitotic events. Infection leads to the elevations in glucose and glutamine consumption rates, while also increasing lactate production rate. Fibroblast lineages are normally quiescent cells that display a repertoire of responses to certain agonists. Data on the shifts in fibroblast metabolism in response to human adenoviral infection are lacking. Specifically, knowledge pertaining to metabolic shifts aside from those involved in glycolytic metabolism after human adenoviral infection remains sparse. We used an untargeted metabolomic approach to better understand the dynamic metabolic changes to fibroblasts in response to 3 viral dosages, across 4 time points post-infection. Profound shifts were seen in cysteine, purine, and unsaturated fatty acid metabolites. This analysis provides a global perspective and highlights previously underappreciated aspects of how human adenovirus alters host metabolism. |
| Institute: | University of California, Merced |
| Last Name: | SANCHEZ |
| First Name: | BAILEY-J |
| Address: | 5200 North Lake Road, MERCED, CALIFORNIA, 95343, USA |
| Email: | Bsanchez59@ucmerced.edu |
| Phone: | 559-978-3565 |
| Funding Source: | USDA HSI Education Training grant (2021-03397) |
Summary of all studies in project PR002259
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003649 | Untargeted metabolomics of Human embryonic kidney cells (HEK293) infected by Human adenovirus serotype 5 during early and late infection. | Homo sapiens | University of California, Merced | MS | 2025-01-26 | 1 | 74 | Not available |
