Summary of project PR002266
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002266. The data can be accessed directly via it's Project DOI: 10.21228/M8QN80 This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002266 |
| Project DOI: | doi: 10.21228/M8QN80 |
| Project Title: | Profiling the human beta cell's molecular metabolic response to glucose |
| Project Type: | Non-target discovery-based FIA-MS profiling |
| Project Summary: | Metabolic homeostasis is maintained in part by pancreatic beta-cells. Understanding the molecular response of beta-cells to glucose fluctuations will uncover potential mechanistic targets to improve beta-cell functionality in diabetes. For this study we undertook a multi-omics approach using proteomics, metabolomics, and transcriptomics to map molecular networks that are changed in response to acute physiologic glucose stimulation in beta-cells purified from human donor islets. Moreover, we developed interactive analytical tools to integrate these multi-omics data sets and exemplify their discovery potential. One such discovery is a significant glucose-driven remodeling of the beta-cell proteome with programmatic increases in mitochondrial structure-function pathways. Surprisingly, this occurs in the absence of increased mitochondrial biogenesis. We find that glucose-regulated structural transitions in mitochondria lead to tightening of cristae junctions to meet the metabolic demand of insulin secretion. By broadening the spectrum of glucose-regulated protein, metabolite and gene networks, this work facilitates discovery of mechanisms for improving beta-cell functionality. |
| Institute: | Dana Farber Cancer Institute |
| Department: | Cancer Biology |
| Laboratory: | Nika Danial |
| Last Name: | Fu |
| First Name: | Accalia |
| Address: | 368 plantation st AS7-2002 |
| Email: | accalia.fu1@umassmed.edu |
| Phone: | 5088563679 |
Summary of all studies in project PR002266
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003656 | Profiling the human beta cell's molecular metabolic response to glucose | Homo sapiens | Dana Farber Cancer Institute | MS | 2026-01-02 | 1 | 10 | Uploaded data (609.6M)* |
