Summary of project PR002280
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002280. The data can be accessed directly via it's Project DOI: 10.21228/M8X534 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002280 |
| Project DOI: | doi: 10.21228/M8X534 |
| Project Title: | Polar Metabolite Profiles Distinguish Between Early and Severe Sub-maintenance Nutritional States of Wild Bighorn Sheep |
| Project Type: | Untargeted NMR Metabolomics |
| Project Summary: | Understanding the metabolic adaptations of wild bighorn sheep (Ovis c. canadensis) to nutritional stress is crucial for their conservation. This study employed 1H nuclear magnetic resonance (NMR) metabolomics to investigate the biochemical responses of these animals to varying sub-maintenance nutritional states. Serum samples from 388 wild bighorn sheep collected between 2014 and 2017 during December through March across Wyoming and Montana were analyzed. Multivariate statistics and machine learning analyses were employed to identify characteristic metabolic patterns and metabolic interactions between early and severe sub-maintenance nutritional states. Significant differences were observed in the levels of 15 of the 49 quantified metabolites, including formate, thymine, glucose, choline, and others, pointing to disruptions in one-carbon, amino acid, and central carbon metabolic pathways. These metabolites may serve as indicators of critical physiological processes such as nutritional intake, immune function, energy metabolism, and protein catabolism, essential for understanding how wild bighorn sheep adapt to nutritional stress. The study has generated valuable insights into molecular networks underlying the metabolic resilience of wild bighorn sheep, highlighting the potential for using specific biochemical markers to evaluate nutritional and energetic states in free-ranging ungulates. These insights may help wildlife man-agers and ecologists compare populations across different times in seasonal cycles, providing information to assess the adequacy of seasonal ranges and support conservation efforts. This research strengthens our understanding of metabolic adaptations to envi-ronmental stressors in wild ruminants, offering a foundation for improving management practices to maintain healthy bighorn sheep populations. |
| Institute: | Montana State University |
| Department: | Chemistry and Biochemistry |
| Laboratory: | PI: Dr. Valerie Copie |
| Last Name: | O'Shea-Stone |
| First Name: | Galen |
| Address: | 103 Chemistry and Biochemistry Building |
| Email: | galenoshea@gmail.com |
| Phone: | 3035237132 |
Summary of all studies in project PR002280
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003675 | Polar Metabolite Profiles Distinguish Between Early and Severe Sub-maintenance Nutritional States of Wild Bighorn Sheep | Ovis canadensis canadensis | Montana State University | NMR | 2025-02-11 | 1 | 398 | Not available |
