Summary of project PR002286
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002286. The data can be accessed directly via it's Project DOI: 10.21228/M84N93 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002286 |
| Project DOI: | doi: 10.21228/M84N93 |
| Project Title: | Physiologic Relevance of Transpulmonary Metabolome in Connective Tissue Disease-Associated Pulmonary Vascular Disease |
| Project Summary: | Previous studies attempted to deduce metabolic changes in the pulmonary vasculature of PAH patients by analyzing their plasma metabolome. The clinical applicability of these findings, however, has been limited by: (i) plasma collection from a single anatomic site reflecting metabolic disturbances of the whole body rather than the pulmonary vessels, and (ii) the incomprehension of how metabolism relates to exercise physiology in PAH. We therefore aimed to quantify the transpulmonary (i.e., across the pulmonary vascular bed via two collection sites per patient per exercise timepoint) plasma metabolome in exercising connective tissue disease patients with suspected or confirmed PAH, with the goal of identifying metabolic signatures specific to the pulmonary vasculature and defining how they relate to physiologic, clinical parameters. |
| Institute: | University of Colorado Anschutz Medical Campus |
| Laboratory: | Angelo D'Alessandro in collaboration with Michael Lee (UCSF) |
| Last Name: | Haines |
| First Name: | Julie |
| Address: | 12801 E 17th Ave, Room 1303, Aurora, Colorado, 80045, USA |
| Email: | julie.haines@cuanschutz.edu |
| Phone: | 3037243339 |
Summary of all studies in project PR002286
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003686 | Characterization of the transpulmonary metabolome at the intersection of pulmonary vascular disease and exercise | Homo sapiens | University of Colorado Anschutz Medical Campus | MS | 2025-02-17 | 1 | 468 | Uploaded data (10.6G)* |
