Summary of project PR002303
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002303. The data can be accessed directly via it's Project DOI: 10.21228/M8XZ66 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002303 |
| Project DOI: | doi: 10.21228/M8XZ66 |
| Project Title: | Integrating Metagenomics and Metabolomics to Study the Gut Microbiome and Host Relationships in Sports Across Different Energy Systems |
| Project Summary: | This study explored the role of the gut microbiome in modulating host metabolism among Colombian athletes by comparing elite weightlifters (n = 16) and cyclists (n = 13) through integrative omics analysis. Fecal and plasma samples collected one month before an international event underwent metagenomic, metabolomic, and lipidomic profiling. Metagenomic analysis via bioBakery tools revealed significant microbial pathways, including L-arginine biosynthesis III and fatty acid biosynthesis initiation. Key metabolic pathways, such as phenylalanine, tyrosine, and tryptophan biosynthesis; arginine biosynthesis; and folate biosynthesis, were enriched in both athlete groups. Plasma metabolomics and lipidomics revealed distinct metabolic profiles and a separation between athlete types through multivariate models, with lipid-related pathways such as lipid droplet formation and glycolipid synthesis driving the differences. Notably, elevated carnitine, amino acid, and glycerolipid levels in weightlifters suggest energy system-specific metabolic adaptations. These findings underscore the complex relationship between the gut microbiota composition and metabolic responses tailored to athletic demands, laying the groundwork for personalized strategies to optimize performance. This research highlights the potential for targeted modulation of the gut microbiota as a basis for tailored interventions to support specific energy demands in athletic disciplines. |
| Institute: | Universidad del Rosario |
| Last Name: | Aya |
| First Name: | Viviana |
| Address: | calle 13 a sur # 7a 28, Bogota, Bogota, 110411, Colombia |
| Email: | jeimmy.aya@urosario.edu.co |
| Phone: | 3143055382 |
Summary of all studies in project PR002303
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003710 | Integrating Metagenomics and Metabolomics to Study the Gut Microbiome and Host Relationships in Sports Across Different Energy Systems | Homo sapiens | Universidad del Rosario | MS | 2025-02-28 | 1 | 42 | Uploaded data (1.1G)* |
