Summary of project PR002329
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002329. The data can be accessed directly via it's Project DOI: 10.21228/M8KJ93 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002329 |
| Project DOI: | doi: 10.21228/M8KJ93 |
| Project Title: | Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling. |
| Project Summary: | Fibroblast Growth Factor (FGF) 21 is a hormone produced mainly by the liver but also other organs, including the heart. Although FGF21 analogs are used for treating obesity and metabolic syndrome in humans, preclinical and clinical studies have elicited mixed results about whether prolonged FGF21 signaling is protective or detrimental for cardiac function. Based on our findings, showing elevated serum and cardiac FGF21 levels in humans with increased left ventricular afterload, we explored involvement of FGF21 in cardiac hypertrophy. Our mouse studies revealed an interorgan liver-heart crosstalk mechanism which is controlled by initial hepatic FGF21 release followed by induction of cardiomyocyte FGF21 expression. Tissue-specific genetic ablation or anti-sense oligonucleotides-based inhibition of FGF21 showed that in response to pressure overload, cardiomyocyte FGF21 upregulation is a critical event that is stimulated by liver-derived FGF21 and drives cardiac hypertrophy likely by interfering with cardioprotective oxytocin signaling. Conclusively, a hepato-cardiac FGF21-based signaling axis governs cardiac hypertrophy. |
| Institute: | University of Cincinnati College of Medicine |
| Last Name: | Siokatas |
| First Name: | Georgios |
| Address: | 231 ALBERT SABIN WAY, University of Cincinnati, Cincinnati, OH, 45267-2827 |
| Email: | siokatgs@ucmail.uc.edu |
| Phone: | 5133028282 |
Summary of all studies in project PR002329
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003743 | Cardiac metabolome signatures of hepato-cardiac FGF21 signaling in pressure overload-induced cardiac hypertrophy | Mus musculus | University of Cincinnati College of Medicine | NMR | 2025-03-04 | 1 | 40 | Uploaded data (37.4M)* |
| ST003851 | Lipidomic signatures of hepato-cardiac FGF21 signaling in pressure overload- induced cardiac hypertrophy | Mus musculus | University of Cincinnati College of Medicine | MS* | 2025-05-01 | 1 | 40 | Uploaded data (1.9G)* |
