Summary of project PR002362
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002362. The data can be accessed directly via it's Project DOI: 10.21228/M89Z6M This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002362 |
| Project DOI: | doi: 10.21228/M89Z6M |
| Project Title: | Study the role of high fat diet and sex hormone fluctuations on visceral or gonadal adipose tissue (GWAT) lipid species |
| Project Type: | MS |
| Project Summary: | This study investigated effects of high fat diet and sex hormone alterations with gonadectomy (GX) on lipid composition in the obese GWAT. Untargeted lipidomics was performed on GWAT from castrated (CAS) male (M) mice and ovariectomized (OVX) female (F) mice. The control groups are named M SHAM HFD and F SHAM HFD, and the experimental groups are named M CAS HFD (or M GX HFD in text) and F OVX HFD (or F GX HFD in text). Untargeted lipidomics of obese GWAT identified sex differences in phospholipids, sphingolipids, sterols, fatty acyls, saccharo-lipids and prenol- lipids. Males had significantly higher content of key precursor fatty acids (palmitic, oleic, linoleic and arachidonic acid) when compared to female and GX mice. These findings of sexual dimorphism in stored lipid species emphasize sex-differences in GWAT lipid metabolism pathways that alter lipid composition driving inflammation responses and metabolic disease risk. |
| Institute: | University of Michigan |
| Department: | BRCF |
| Laboratory: | Metabolomics core |
| Last Name: | Kachman |
| First Name: | Maureen |
| Address: | 1000 Wall St. |
| Email: | mkachman@med.umich.edu |
| Phone: | 734-232-0842 |
Summary of all studies in project PR002362
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003785 | Sex differences in lipid profiles of visceral adipose tissue with obesity and gonadectomy | Mus musculus | University of Michigan | MS | 2025-03-31 | 1 | 24 | Uploaded data (2.1G)* |
