Summary of project PR002367
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002367. The data can be accessed directly via it's Project DOI: 10.21228/M8P55Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002367 |
| Project DOI: | doi: 10.21228/M8P55Q |
| Project Title: | Associations between lipoprotein subclasses and cardiovascular health in ageing |
| Project Summary: | Abnormal lipoprotein profiles have been frequently described in association with atherogenic cardiovascular diseases. The relevance of lipoproteins in human cardiovascular health with ageing, which commonly manifests as heart failure in older adults, is less often investigated. Capitalizing on 1H NMR spectroscopy which identifies lipoprotein subclasses with great detail, we explored in-depth associations between 112 lipoproteins and cardiac function of N=474 unique older adults, hypothesizing that specific lipoproteins may be associated with cardiac ageing.Decreases in intermediate density LDLs (1.034-1.037 g/mL) and increases in intermediate density VLDLs (0.961-0.995 g/mL) were observed among older adults with poorer cardiac function. There was heterogeneous distribution of low density (0.950-0.961 g/mL) VLDL fractions, which became more prominent in patients with poor cardiac function. Prominent apolipoprotein-A increases specific to those with poorer cardiac function were observed among those taking lipid lowering medications, localized to specific lower density HDL fractions (1.063-1.112 g/mL). |
| Institute: | Nanyang Technological University |
| Department: | Lee Kong Chian School of Medicine |
| Laboratory: | Singapore Phenome Centre |
| Last Name: | Yu King Hing |
| First Name: | Nathaphon |
| Address: | 59 Nanyang Drive Singapore |
| Email: | joel.yukh@ntu.edu.sg |
| Phone: | 83199405 |
Summary of all studies in project PR002367
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003791 | Associations between lipoprotein subclasses and cardiovascular health in ageing | Homo sapiens | Nanyang Technological University | NMR | 2025-03-14 | 1 | 474 | Uploaded data (1G)* |
