Summary of project PR002373
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002373. The data can be accessed directly via it's Project DOI: 10.21228/M8WR76 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002373 |
| Project DOI: | doi: 10.21228/M8WR76 |
| Project Title: | Metabolic signature in combination with fecal immunochemical test (FIT) as a tool for colorectal cancer diagnosis |
| Project Summary: | Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Even though the screening programs have decreased the incidence rates, the prognosis for CRC varies depending on the stage at the diagnosis. Thus, early diagnosis is still a big challenge due to screening methods, and subsequent diagnosis are not very sensitive. In this work, LC-MS based metabolomics, a powerful and sensitive tool to study complex dynamic changes, was used to analyse 211 human fecal samples from control individuals (CTRL), adenoma (AA), and CRC patients. Multivariate and univariate statistical analysis highlighted cholesteryl esters (CE) and fecal haemoglobin, quantified by fecal immunochemical test (FIT), as relevant biomarkers that clearly differentiate CRC from AA and CTRL. This study revealed that AA group is a transitionary stage with a high heterogeneity. The increased tendency observed in CEs from CTRL to CRC might be related with the imbalance of cholesterol homeostasis due to cancer cells requiring high cholesterol level for cell development and proliferation. The free cholesterol is probably obtained from CEs as it is the most effective way to obtain the needed cholesterol. |
| Institute: | CICbiogUNE |
| Last Name: | Alboniga |
| First Name: | Oihane |
| Address: | Bizkaia Technology Park, Bld.800, Derio, Bizkaia, 48160, Spain |
| Email: | oalboniga@cicbiogune.es |
| Phone: | +34944061317 |
Summary of all studies in project PR002373
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003798 | Metabolic signature in combination with fecal immunochemical test as a non-invasive tool for advanced colorectal neoplasia diagnosis | Homo sapiens | CICbiogUNE | MS | 2025-07-15 | 1 | 211 | Uploaded data (19.6G)* |
