Summary of project PR002389
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002389. The data can be accessed directly via it's Project DOI: 10.21228/M8TR66 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002389 |
| Project DOI: | doi: 10.21228/M8TR66 |
| Project Title: | Irisin Attenuates Postmenopausal Osteoporosis by Upregulating Phosphatidylcholine Metabolism via the Wnt/β-catenin Pathway |
| Project Summary: | Irisin can ameliorate postmenopausal osteoporosis (PMOP) in ovariectomized (OVX) mice by promoting osteogenesis, inhibiting adipogenesis, and regulating the bone-fat balance. Similarly, irisin enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells (BMSCs) in vitro while reducing their adipogenic differentiation. Metabolomic analysis of mouse plasma revealed that the therapeutic effects of irisin are associated with pathways such as glycerophospholipid metabolism, wherein the metabolite phosphatidylcholine (PC) plays a significant role. Irisin can upregulate the metabolism of PC in OVX mice, thereby improving OP. We further investigated the metabolic role of PC and its mechanisms. By administering PC to BMSCs, we observed its effects on BMSCs and the underlying mechanisms. It was found that PC activates the canonical Wnt/β-catenin signaling pathway, promoting the osteogenic differentiation of BMSCs while inhibiting their adipogenic differentiation. |
| Institute: | Huizhou Central People's Hospital |
| Department: | Department of Traumatology and Orthopaedic Surgery, Orthopaedic Institute |
| Last Name: | Zhang |
| First Name: | Zhiwen |
| Address: | No. 41, Eling North Road, Huicheng District, Huizhou City, Guangdong Province, Guangdong Province, Huizhou City, Guangdong Province, 516001, China |
| Email: | 13794539802@163.com |
| Phone: | 13794539802 |
Summary of all studies in project PR002389
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003818 | Irisin Attenuates Postmenopausal Osteoporosis by Upregulating Phosphatidylcholine Metabolism via the Wnt/β-catenin Pathway | Mus musculus | Huizhou Central People's Hospital | MS | 2025-04-21 | 1 | 24 | Uploaded data (9.7G)* |
