Summary of project PR002423
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002423. The data can be accessed directly via it's Project DOI: 10.21228/M8FC13 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002423 |
| Project DOI: | doi: 10.21228/M8FC13 |
| Project Title: | Fatty-acid oxidation is a metabolic hallmark of human proliferative retinopathy |
| Project Summary: | In this experiment, we used nontargeted metabolomics to measure metabolite profiles of vitreous humor from subjects with proliferative diabetic retinopathy. Vitreous samples were collected adjacent to leaky pathological neovascular tufts that characterize PR. Amongst the top 25 most significantly dysregulated metabolites, we observed an accumulation of acylcarnitines in human neovascular PR samples compared to control subjects with epiretinal membranes. |
| Institute: | Broad Institute of MIT and Harvard |
| Department: | Metabolomics Platform |
| Last Name: | Clish |
| First Name: | Clary |
| Address: | 300 BineyStreet, Cambridge, MA, 02142, USA |
| Email: | clary@broadinstitute.org |
| Phone: | 617-714-7654 |
| Publications: | submitted |
| Contributors: | Gael Cagnone, Sheetal Pundir, Charlotte Betus, Tapan Agnihotri, Anli Ren, Jin SungKim, Noémie-Rose Harvey, Emilie Heckel, Mei Xi Chen, Anu Situ, Perrine Gaub, Nicholas Kim, Ashim Das, Severine Leclerc, Florian Wünnemann, Louis Berillon, Gregor Andelfinger, Sergio Crespo-Garcia, Alexandre Dubrac, Flavio A. Rezende, Clary B. Clish, Bruno Maranda, José Carlos Rivera, Lois E. H. Smith, Przemyslaw Sapieha, JeanSébastien Joyal |
Summary of all studies in project PR002423
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003867 | Fatty-acid oxidation is a metabolic hallmark of human proliferative retinopathy | Homo sapiens | Broad Institute of MIT and Harvard | MS | 2025-05-01 | 1 | 18 | Uploaded data (3.9G)* |
