Summary of project PR002452
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002452. The data can be accessed directly via it's Project DOI: 10.21228/M8PR93 This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002452 |
| Project DOI: | doi: 10.21228/M8PR93 |
| Project Title: | An anaerobic pathogen operates oxidative metabolism to colonize the inflamed intestine |
| Project Type: | Untargeted Metabolomics analysis |
| Project Summary: | In contrast to the facultative pathogens, ETBF is canonically classified as an obligate anaerobe that is susceptible to oxygen toxicity and reliant on anaerobic fermentation for energy production. How ETBF successfully colonizes the inflamed gut, an environment enriched in oxygen and inflammatory mediators46, has remained unclear. Here, we demonstrate that ETBF leverages its virulence factor BFT to reprogram epithelial cell metabolism, thereby reshaping the gut nutritional landscape. This reprogramming leads to increased levels of lactate and oxygen, which fuel ETBF's unique oxidative metabolism, challenging the long-standing view of B. fragilis as strictly anaerobic. Our findings uncover a novel mechanism by which an obligate anaerobe reshapes its environment to establish an oxidative metabolic niche and promote its own expansion in the inflamed gut. |
| Institute: | Vanderbilt University |
| Department: | Chemistry |
| Laboratory: | Center for Innovative Technology |
| Last Name: | CODREANU |
| First Name: | SIMONA Gabriela |
| Address: | 1234 STEVENSON CENTER LANE |
| Email: | SIMONA.CODREANU@VANDERBILT.EDU |
| Phone: | 6158758422 |
Summary of all studies in project PR002452
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003919 | An anaerobic pathogen operates oxidative metabolism to colonize the inflamed intestine | Mus musculus | Vanderbilt University | MS* | 2025-11-09 | 1 | 8 | Uploaded data (6.3G)* |
