Summary of project PR002474
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002474. The data can be accessed directly via it's Project DOI: 10.21228/M8V84X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002474 |
| Project DOI: | doi: 10.21228/M8V84X |
| Project Title: | Plasma Metabolomic Analysis in Thai EGFR-mutated Non-Small Cell Lung Cancer Patients |
| Project Summary: | Lung cancer remains the leading cause of cancer-related deaths worldwide, emphasizing an urgent need for effective, non-invasive diagnostic and prognostic biomarkers. Metabolic reprogramming driven by oncogenic driver alterations, especially EGFR mutations in non-small cell lung cancer (NSCLC), provides promising metabolic signatures detectable in plasma. This study aimed to identify plasma metabolomic biomarkers distinguishing healthy individuals from NSCLC patients and to further stratify NSCLC patients by EGFR mutation status and EGFR tyrosine kinase inhibitor (TKI) resistance. Using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS/MS), we quantified four groups of targeted metabolites (amino acids, organic acids, sugar and sugar alcohols, and phospholipids) of 78 individuals, including NSCLC patients and healthy controls. Metabolomic signatures distinctly separated healthy controls from NSCLC patients and, furthermore, EGFR-mutated NSCLC from EGFR wild-type cases. Additionally, metabolomics results effectively distinguished EGFR TKI-resistant from treatment-naïve EGFR-mutated NSCLC. Our findings highlight the potential of plasma metabolites as minimally invasive biomarkers for molecular classification and monitoring therapeutic response in NSCLC patients. |
| Institute: | Mahidol University |
| Last Name: | Khoomrung |
| First Name: | Sakda |
| Address: | 2 Wanglang road, Bangkoknoi, Bangkok 10700. Thailand. |
| Email: | Sakda.kho@mahidol.edu |
| Phone: | 024195505 |
Summary of all studies in project PR002474
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003950 | Plasma Phospholipids Analysis in Thai EGFR-mutated Non-Small Cell Lung Cancer Patients | Homo sapiens | Mahidol University | MS | 2025-07-07 | 1 | 78 | Uploaded data (24M)* |
| ST003989 | Plasma Amino Acids Analysis in Thai EGFR-mutated Non-Small Cell Lung Cancer Patients | Homo sapiens | Mahidol University | MS | 2025-07-07 | 1 | 78 | Uploaded data (214.6M)* |
| ST004177 | Plasma Organic acids Analysis in Thai EGFR-mutated Non-Small Cell Lung Cancer Patients | Homo sapiens | Mahidol University | MS | 2025-09-16 | 1 | 78 | Uploaded data (4.6G)* |
| ST004184 | Plasma Sugar and Sugar Alcohols Analysis in Thai EGFR-mutated Non-Small Cell Lung Cancer Patients | Homo sapiens | Mahidol University | MS | 2025-10-06 | 1 | 78 | Uploaded data (12.8G)* |
