Summary of project PR002485
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002485. The data can be accessed directly via it's Project DOI: 10.21228/M8F25H This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002485 |
| Project DOI: | doi: 10.21228/M8F25H |
| Project Title: | Effect of Desiccation of Mycobacterium tuberculosis metabolism |
| Project Summary: | The goal of this project was to measure metabolite shifts in Mycobacterium tuberculosis (Mtb) in response to desiccation and rehydration. We characterized the metabolome of Mtb in log phase and compared it to cells that were either dried for 24 hours or held in a solution of 200 mM sodium chloride. Following this incubation cells were rehydrated into 200 mM sodium chloride. We performed targeted metabolomics on each of these conditions using LC-MS. Significant increases in oxidized nucleotides and intermediates of de novo nucleotide biosynthesis were discovered in the desiccated samples. These metaboite accumulations reversed with rehydration. |
| Institute: | Weill Cornell Medicine |
| Department: | Department of Medicine, Division of Infectious Diseases |
| Laboratory: | Rhee Lab |
| Last Name: | Brown |
| First Name: | Christopher |
| Address: | 413 E 69th St, New York, NY, 10021, USA |
| Email: | cdb9006@med.cornell.edu |
| Phone: | 6469626225 |
| Funding Source: | P01AI159402 (PI: Rhee) |
| Publications: | https://doi.org/10.1101/2025.06.04.657859 |
Summary of all studies in project PR002485
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003969 | Effect of Desiccation of Mycobacterium tuberculosis metabolism | Mycobacterium tuberculosis (H37Rv) | Weill Cornell Medicine | MS | 2025-07-07 | 1 | 90 | Uploaded data (3.4G)* |
