Summary of project PR002491
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002491. The data can be accessed directly via it's Project DOI: 10.21228/M8NN8C This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002491 |
| Project DOI: | doi: 10.21228/M8NN8C |
| Project Title: | Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling |
| Project Summary: | Understanding how extracellular glucose regulates adipose tissue remodeling is key to decoding metabolic health. Here, we show that the histone demethylase JMJD1A senses glucose availability via α-ketoglutarate (α-KG), a TCA cycle metabolite derived from glycolysis. Upon glucose stimulation, α-KG accumulates in the nucleus and activates JMJD1A to remove repressive H3K9me2 marks at glycolytic and adipogenic gene loci, including Pparg. This initiates a transcriptional feedforward loop that amplifies glycolysis and de novo adipogenesis. Mechanistically, JMJD1A is pre-recruited to chromatin by NFIC, and glucose-induced demethylation enables subsequent ChREBP binding. In vivo, mice lacking JMJD1A in adipocyte precursors exhibit impaired adipose tissue hyperplasia and compensatory hypertrophic expansion selectively in visceral fat, resulting in metabolically unfavorable remodeling. These findings uncover a glucose-sensing α-KG-JMJD1A pathway that regulates histone demethylation and de novo adipogenesis, enabling adaptive expansion of visceral adipose tissue under nutrient excess conditions. |
| Institute: | Tohoku University |
| Last Name: | Sakai |
| First Name: | Juro |
| Address: | 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan |
| Email: | juro.sakai.b6@tohoku.ac.jp |
| Phone: | +81-22-717-8117 |
Summary of all studies in project PR002491
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003976 | Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling (Study part 6 of 1) | Mus musculus | Tohoku University | MS | 2025-07-07 | 1 | 15 | Uploaded data (33.5G)* |
| ST003977 | Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling (Study part 6 of 2) | Mus musculus | Tohoku University | MS | 2025-07-07 | 1 | 10 | Uploaded data (16.2G)* |
| ST003978 | Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling (Study part 6 of 3) | Mus musculus | Tohoku University | MS | 2025-07-07 | 1 | 10 | Uploaded data (16G)* |
| ST003979 | Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling (Study part 6 of 4) | Mus musculus | Tohoku University | MS | 2025-07-07 | 1 | 18 | Uploaded data (54.4G)* |
| ST003985 | Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling (Study part 6 of 5) | Mus musculus | Tohoku University | MS | 2025-07-07 | 1 | 4 | Uploaded data (9.2G)* |
| ST003987 | Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling (Study part 6 of 6) | Mus musculus | Tohoku University | MS | 2025-07-07 | 1 | 4 | Uploaded data (2.1G)* |
