Summary of project PR002514

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002514. The data can be accessed directly via it's Project DOI: 10.21228/M8PG32 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR002514
Project DOI:doi: 10.21228/M8PG32
Project Title:Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance
Project Summary:This metabolomics dataset supports research into new antimalarials by examining resistance to ZY19489. A N246H mutation in the P. falciparum chloroquine resistance transporter (PfCRT) confers low-grade ZY19489 resistance, reduces parasite fitness, and maintains sensitivity to piperaquine and other 4-aminoquinolines. Metabolomic analyses show that ZY19489 treatment lowers hemoglobin-derived peptide levels and increases pyrimidine intermediates, suggesting effects on hemoglobin degradation and pyrimidine biosynthesis. These findings highlight a resistance marker and support the use of ZY19489-PPQ combination therapy to limit resistance emergence.
Institute:Pennsylvania State University
Last Name:Llinas
First Name:Manuel
Address:W126 Millenium Science Complex, University Park, PA 16802
Email:manuel@psu.edu
Phone:814-867-3527

Summary of all studies in project PR002514

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST004017 Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance Plasmodium falciparum Pennsylvania State University MS 2025-12-15 1 31 Uploaded data (10.2G)*
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