Summary of project PR002523
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002523. The data can be accessed directly via it's Project DOI: 10.21228/M8HR85 This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002523 |
| Project DOI: | doi: 10.21228/M8HR85 |
| Project Title: | Spatial isotope deep tracing deciphers inter-tissue metabolic crosstalk |
| Project Summary: | Organs collaborate to maintain metabolic homeostasis in mammals. Spatial metabolomics makes strides in profiling the metabolic landscape, yet can not directly inspect the metabolic crosstalk between tissues. Here, we introduce an approach to comprehensively trace the metabolic fate of 13C-nutrients within the body and present a robust computational tool, MSITracer, to deep-probe metabolic activity in a spatial manner. By discerning spatial distribution differences between isotopically labeled metabolites from ambient mass spectrometry imaging-based isotope tracing data, this approach empowers us to characterize fatty acid metabolic crosstalk between the liver and heart, as well as glutamine metabolic exchange across the kidney, liver, and brain. Moreover, we disclose that tumor burden significantly influences the host’s hexosamine biosynthesis pathway, and that the glucose-derived glutamine released from the lung as a potential source for tumor glutamate synthesis. The developed approach facilitates the systematic characterization of metabolic activity in situ and the interpretation of tissue metabolic communications in living organisms. |
| Institute: | Peking Union Medical College |
| Last Name: | Li |
| First Name: | Xinzhu |
| Address: | No. 2, South Weilu, Xicheng District, Beijing |
| Email: | liting@imm.ac.cn |
| Phone: | 15239480561 |
Summary of all studies in project PR002523
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004031 | Spatial isotope deep tracing deciphers inter-tissue metabolic crosstalk | Mus musculus | Peking Union Medical College | MS* | 2025-07-11 | 1 | 778 | Uploaded data (17.2G)* |
