Summary of project PR002553
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002553. The data can be accessed directly via it's Project DOI: 10.21228/M8NC2B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002553 |
| Project DOI: | doi: 10.21228/M8NC2B |
| Project Title: | Development of Novel Pancreatic Cancer Diagnostic Biomarkers via Lipidomic Profiling |
| Project Summary: | Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy due to late diagnosis and the lack of sensitive screening tools. We recently discovered that tumors depend on circulating fatty acids as a major energy source. Accordingly, we conducted a study to identify screening-diagnostic biomarkers for PDAC in the lipid fraction of patient plasma. In this study, we performed non-targeted lipidomics on human and mouse plasma samples and identified eight concordant lipid metabolites. We then established four targeted-lipidomics platforms—acylcarnitines, phospholipids, fatty acid amides, and sphingolipids—and carried out quantitative analysis in two independent patient cohorts. A combined tertiary analysis of both cohorts revealed 20 lipid species (1 acylcarnitine, 1 sphingolipid, and 18 phospholipids) that achieved an AUC ≥ 0.75 for discriminating PDAC patients from healthy controls. A logistic regression model incorporating 11 or more phospholipids yielded an AUC of 0.9207, which further increased to 0.9427 in the validation cohort upon addition of CA19-9. While extensive validation in larger, multicenter cohorts is necessary, these findings highlight the promise of a lipid biomarker panel and multivariate algorithms as novel metabolic indicators for early PDAC diagnosis. |
| Institute: | National Cancer Center Graduate School of Cancer Science and Policy |
| Last Name: | Kang |
| First Name: | Joon Hee |
| Address: | 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, South Korea |
| Email: | wnsl2820@gmail.com |
| Phone: | 82-031-920-2227 |
Summary of all studies in project PR002553
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004066 | Development of Novel Pancreatic Cancer Diagnostic Biomarkers via Lipidomic Profiling - Untargeted metabolomics in human plasma | Homo sapiens | National Cancer Center Graduate School of Cancer Science and Policy | MS* | 2025-10-22 | 1 | 227 | Uploaded data (561.4M)* |
| ST004067 | Development of Novel Pancreatic Cancer Diagnostic Biomarkers via Lipidomic Profiling - Untargeted metabolomics in mice plasma | Mus musculus | National Cancer Center Graduate School of Cancer Science and Policy | MS* | 2025-10-22 | 1 | 33 | Uploaded data (170.4M)* |
| ST004073 | Development of Novel Pancreatic Cancer Diagnostic Biomarkers via Lipidomic Profiling - targeted metabolomics of human plasma | Homo sapiens | National Cancer Center Graduate School of Cancer Science and Policy | MS | 2025-10-22 | 1 | 344 | Uploaded data (50.8M)* |
