Summary of project PR002571
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002571. The data can be accessed directly via it's Project DOI: 10.21228/M89V6K This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002571 |
| Project DOI: | doi: 10.21228/M89V6K |
| Project Title: | Metabolite profiling of Ankrd55-/- TH17 Cells |
| Project Summary: | Genome-wide association studies (GWAS) have linked the locus encoding Ankyrin Repeat Domain 55 (ANKRD55) with numerous autoimmune diseases; however, its biological function and role in inflammation are unclear. Here, we demonstrate that Ankrd55-deficient mice are protected from T cell-mediated colitis but are more susceptible to Citrobacter rodentium infection. Mechanistically, Ankrd55 deletion impairs CD4+ T cell proliferation and reduces effector cytokine production in T helper 17 (TH17) cells in a cell-intrinsic manner. ANKRD55 is associated with mitochondria, and its loss is associated with impaired mitochondrial respiration and activation of the LKB1 pathway. Consistently, IL-17 production can be rescued by the deletion of LKB1 in Ankrd55-deficient T cells. Altogether, our study implicates the protein ANKRD55 as a functional modulator of T cell metabolism that directly impacts TH17 responses, highlighting it as a potential target across multiple autoimmune diseases. |
| Institute: | Broad Institute of MIT and Harvard |
| Last Name: | Xavier |
| First Name: | Ramnik |
| Address: | 415 Main Street |
| Email: | rxavier@broadinstitute.org |
| Phone: | +1 (617) 714-7379 |
| Project Comments: | Jinjin Xu, Lingjia Kong, Elizabeth A. Creasey, Sneha Rath, Lei Deng, Julian Avila-Pacheco, Chenhao Li, Blayne A. Oliver, Tyler Dao, Angela R. Shih, Mark J. Daly, Alex K. Shalek, Clary B. Clish, Daniel B. Graham, Jacques Deguine |
Summary of all studies in project PR002571
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004093 | Autoimmune Disease Risk Gene ANKRD55 Promotes T Cell Proliferation and Th17 2 Effector Function Through Metabolic Modulation | Mus musculus | Broad Institute of MIT and Harvard | MS* | 2025-08-14 | 1 | 16 | Uploaded data (11.4G)* |
