Summary of project PR002576
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002576. The data can be accessed directly via it's Project DOI: 10.21228/M8P563 This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002576 |
| Project DOI: | doi: 10.21228/M8P563 |
| Project Title: | Combined bacterial infection and radiation injury in the murine model: Consequences on metabolomics based biodosimetry |
| Project Summary: | High-throughput biodosimetry assays are needed to assess ionizing radiation (IR) exposure in emergency situations that can predict the level of acute radiation syndrome (ARS) across a heterogenous segment of the population that may have secondary bacterial infections or combined injury. In this study, we investigate the impact of bacterial infection on metabolite-based biodosimetry using a well-established model: recombinant Listeria monocytogenes expressing ovalbumin (Lm-OVA) and C57BL/6 murine infection model. Male mice were infected with Lm-OVA, then subjected to 0, 2, or 6 Gy X-ray irradiation at 4 days post-infection (dpi). Biofluids were analyzed using untargeted metabolomics at 1 day (d) post-irradiation (5 dpi). |
| Institute: | Georgetown University |
| Last Name: | Pannkuk |
| First Name: | Evan |
| Address: | 3970 Reservoir Rd, NW New Research Build, washington dc, District of Columbia, 20057, USA |
| Email: | elp44@georgetown.edu |
| Phone: | 2026875650 |
Summary of all studies in project PR002576
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004100 | Combined bacterial infection and radiation injury in the murine model: Consequences on metabolomics based biodosimetry (Serum analysis) | Mus musculus | Georgetown University | MS* | 2026-01-02 | 1 | 37 | Uploaded data (46.1G)* |
| ST004101 | Combined bacterial infection and radiation injury in the murine model: Consequences on metabolomics based biodosimetry (Urine analysis) | Mus musculus | Georgetown University | MS* | 2026-01-02 | 1 | 37 | Uploaded data (48.1G)* |
